Long-term Clinical Outcome in Patients with Pineal Germinoma

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  • 松果体部Ｇｅｒｍｉｎｏｍａの長期予後
  • ショウカタイブ Germinoma ノ チョウキ ヨゴ

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Background and Aims : We retrospectively analyzed the long-term clinical course of 10 patients with pineal germinomas to determine the best treatment modality for achieving a good outcome.<BR>Methods : Subjects were treated at the Gunma University Hospital between 1980 and 1998, given a total dose of 40-50 Gy (mean : 49 Gy) delivered under a conventional fractionation schedule.<BR>esults : Tumors had shrunk at 20 Gy in all 10 patients. Mean follow-up was 13.5 years (162 months, range, 59 to 268 months). Five-year survival for the group was 100%. None experienced intracranial disease recurrence. No new abnormalities in internal secretion considered to be due to radiotherapy were seen. Karnofsky performance scales (KPS) for 8 of the 10 were 100. KPS of the remaining 2 were 80, including easy fatiguability, mild ataxia, and recent memory disturbance.<BR>Conclusions : Administration of doses of 50 Gy for pineal germinoma is adequate for controlling the tumor over the long term but may reduce the patient's quality of life. Further study is therefore needed to determine the optimal dosage for pineal germinoma.

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