微細骨粉含浸多孔質アパタイトブロックの異所性骨形成に及ぼす栄養貫通孔の効果

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  • 峯野 誠司
    東京医科歯科大学大学院医歯学総合研究科顎顔面頸部機能再建学系専攻顎顔面機構制御学講座顎顔面解剖学分野

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  • Effects of Nutrient Channels on Ectopic Bone Formation in Porous Apatite Blocks Impregnated with Super Fine Bone Powder
  • ビサイ コップン ガンシン タコウシツ アパタイト ブロック ノ イショセイ コツケイセイ ニ オヨボス エイヨウ カンツウコウ ノ コウカ

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In this study, we prepared four types of 10-mm-diameter, 10-mm-long, large, columnar, bone powder-impregnated, porous apatite blocks, which did or did not have a single nutrient channel of 1, 2, or 3 mm in diameter in the longaxis direction. We implanted them in the subcutaneous tissue of adult dogs for 4, 8, or 16 weeks, and examined the status of bone formation in each block. As a result, bone formation started with the differentiation of osteoblasts along the wall of macro-pores within an area of dense multinucleated cells, and the area of bone formation consisting of bone along the pore wall and bone marrow in the pores gradually expanded around the block in a ring fashion and inward or outward. In apatite blocks with a 2-or 3-mm nutrient channel, bone formation also proceeded along the channel in the block. At 16 weeks after implantation, even in the middle level, almost the entire porous apatite block with a 3-mm channel became the area of bone formation. However, in other apatite blocks, there remained an area without bone formation ; in particular, in blocks without a nutrient channel or with a 1-mm nutrient channel, there remained an area slightly over 4 mm in diameter without bone formation at the middle level. These findings indicate the importance of the nutrient channel for good bone formation in large blocks.

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