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- 服部 重孝
- 東京医科歯科大学大学院医歯学総合研究科顎顔面頸部機能再構築学系専攻顎顔面機構制御学講座顎顔面解剖学分野
書誌事項
- タイトル別名
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- Structural Features of Ectopic Bone-like Tissue in Porous Hydroxyapatite Blocks
- タコウシツ ハイドロキシアパタイトナイ ニ ケイセイサレル イショセイ コツヨウ ソシキ ノ コウゾウテキ トクチョウ
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説明
Calcium phosphate ceramics are widely used as bone substitutes because of their favorable biocompatibility and osteoconductivity. Some studies have reported that porous hydroxyapatite (HA), with its special structure, implanted at ectopic (non-bone) sites, exhibits osteoinductive activity. However, few studies have examined the detailed ultrastructure of mineralized tissue formed in biomaterials like HA. Therefore, it is important to examine whether the mineralized tissue exhibits structural characteristics of normal bone tissue. Thus, in this study, we subcutaneously implanted hydroxyapatite blocks (5×5×7mm) into the backs of adult dogs, and performed detailed morphological examination of the bone-like tissue formed, which showed a lamellar structure. Immunohistochemical staining revealed that the matrix fibers of the bone-like tissue were mainly composed of type I collagen. The pattern of crystal deposition in matrix fibers and the structure of osteoclast-, osteocyte-, bone-lining-, and osteoclast-like cells were similar to those of normal bone tissue and osteogenic cells, respectively. These results indicate that cellular events observed in normal bone formation and remodeling occur in bone-like tissue as well, and suggest that bone-like tissue in HA blocks is very similar to bone tissue.
収録刊行物
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- 口腔病学会雑誌
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口腔病学会雑誌 75 (2), 120-137, 2008
口腔病学会
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詳細情報 詳細情報について
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- CRID
- 1390282681320109440
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- NII論文ID
- 130004098765
- 10024176659
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- NII書誌ID
- AN00302674
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- ISSN
- 18845185
- 03009149
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- NDL書誌ID
- 9563986
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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