Seeking Objective Diagnostic Biomarkers for Mental Disorders :

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  • Mikuni Masahiko
    Department of Psychiatry and Neuroscience, Gunma University Graduate School of Medicine Department of Psychiatry, International University of Health and Welfare Hospital

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  • 精神疾患の客観的診断バイオマーカーの探索
  • 精神疾患の客観的診断バイオマーカーの探索 －山の向こうに山あり，山また山－
  • セイシン シッカン ノ キャッカンテキ シンダン バイオマーカー ノ タンサク : ヤマ ノ ムコウニヤマ アリ,ヤマ マタ ヤマ
  • Climbing to the Summit of a Mountain often Provides a New View towards a Continuous Series of Mountain Summits Yet to Be Attained
  • - 山の向こうに山あり，山また山 -

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Abstract

A central problem in clinical psychiatry is that in the absence of objective diagnostic biomarkers for mental disorders, psychiatrists depend on subjective examinations in order to properly diagnose their patients. Many researchers have studied genetics and investigated objective tools such as magnetic resonance imaging for use as diagnostic markers to aid subjective examinations. None of these findings, however, have been replicated consistently enough to merit widespread clinical use.<br>In this article, I would like to describe briefly the trajectory of my life's work from cancer research to biomarker research for mental disorders, seeking for developing technical innovation in the practice of medical psychiatry. It was the excellent advance in psychiatric practice that a Near Infrared Spectroscopy (NIRS) technique has been exclusively approved by the Ministry of Health, Labour and Welfare as one of dozens of the Advanced Medical Technology to assist in the differential diagnoses of depressive states. However, a search for more essential biomarkers should be continued, to offer better care to people with mental-health problems.

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