Shedding of herpes simplex virus type 1 into saliva after surgery for oral and genital or urological cancer parients.

KAMEYAMA TADAMITSU, HAIKATA KOJI, NAKAMURA YOSHIAKI, MURASE HIROSHI, YAMAMOTO SHIGERU

doi:10.2739/kurumemedj.36.117

Shedding of herpes simplex virus type 1 into saliva after surgery for oral and genital or urological cancer parients.

DOI PubMed オープンアクセス

KAMEYAMA TADAMITSU

Department of Oral Surgery Kurume University School of Medicine
HAIKATA KOJI

Department of Oral Surgery Kurume University School of Medicine
NAKAMURA YOSHIAKI

Department of Oral Surgery Kurume University School of Medicine
MURASE HIROSHI

Department of Oral Surgery Kurume University School of Medicine
YAMAMOTO SHIGERU

Department of Virology Kurume University School of Medicine

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説明

The shedding of herpes simplex virus type-1 (HSV-1) into the saliva was compared in 28 patients with oral cancer and 26 patients with genital or urological cancer. All subjects tested positive for HSV-1 specific antibody. A statistically significant (p<0.001) difference was found: infectious viruses were isolated from 12 (39.8%) of the oral cancer patients versus only 2 (7.6%) of the genital or urological patients. This indicates that direct stimulation of peripheral nerves during surgery was responsible for the greater reactivation of HSV-1.