A STUDY OF EXPERIMENTAL OVARIAN TUMORS PRODUCED IN RATS BY THE CHEMICAL CARCINOGEN, 20-METHYLCHOLANTHRENE

KATO TOSHI, YAKUSHIJI MICHIAKI, TSUNAWAKI AKITSU, IDE KAIKITSU

doi:10.2739/kurumemedj.20.159

A STUDY OF EXPERIMENTAL OVARIAN TUMORS PRODUCED IN RATS BY THE CHEMICAL CARCINOGEN, 20-METHYLCHOLANTHRENE

DOI

KATO TOSHI

Department of Obstetrics and Gynecology, Kurume University School of Medicine
YAKUSHIJI MICHIAKI

Department of Obstetrics and Gynecology, Kurume University School of Medicine
TSUNAWAKI AKITSU

Department of Obstetrics and Gynecology, Kurume University School of Medicine
IDE KAIKITSU

Department of Obstetrics and Gynecology, Kurume University School of Medicine

抄録

In an attempt to produce experimental ovarian tumors, a study was carried out burying silk sutures soaked with 20-Methylcholanthrene in the ovaries of rats. Fourteen solid tumors were produced in 100 animals. The minimum time for tumor production was 21 weeks, and the tumor production rate was 22.5% after 41 weeks. Histologically 8 tumors were sarcomas, 5 adenocarcinomas, and 1 was a granulosa cell tumor, of the 8 sacromas, 3 were transplantable, being currently transplanted in the 7th, 5th, and 4th generations.