Association between Thromboembolic Events and the <I>JAK2</I> V617F Mutation in Myeloproliferative Neoplasms
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- TAKATA YUKA
- Department of Medicine, Kurume University School of Medicine
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- SEKI RITSUKO
- Department of Medicine, Kurume University School of Medicine
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- KANAJII TAISUKE
- Department of Medicine, Kurume University School of Medicine
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- NOHARA MASAYUKI
- Department of Medicine, Kurume University School of Medicine
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- KOTEDA SATOKO
- Department of Medicine, Kurume University School of Medicine
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- KAWAGUCHI KUNIKI
- Department of Medicine, Kurume University School of Medicine
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- NOMURA KEI
- Department of Medicine, Kurume University School of Medicine
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- NAKAMURA TAKAYUKI
- Department of Medicine, Kurume University School of Medicine
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- MORISHIGE SATOSHI
- Department of Medicine, Kurume University School of Medicine
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- OKU EIJIROU
- Department of Medicine, Kurume University School of Medicine
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- OSAKI KOICHI
- Department of Medicine, Kurume University School of Medicine
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- HASHIGUCHI EMICHITOSHI
- Department of Medicine, Kurume University School of Medicine
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- MOURI FUMIHIKO
- Department of Medicine, Kurume University School of Medicine
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- YOSHIMOTO KOJI
- Department of Medicine, Kurume University School of Medicine
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- NAGAFUJI KOJI
- Department of Medicine, Kurume University School of Medicine
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- OKAMURA TAKASHI
- Department of Medicine, Kurume University School of Medicine
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Description
Thrombotic complications are a major cause of death in patients with Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs), which are closely associated with the JAK2 V617F activating mutation. However, whether the presence of the JAK2 V617F mutation affects thrombotic risk is currently unknown, although some reports have suggested a variable association with thrombosis. Therefore, we investigated the association between JAK2 V617F and various complications, including thrombosis, in Japanese patients with MPNs. We assessed the JAK2 V617F status in 140 patients who were diagnosed or doubted as having some type of MPN by utilizing a JAK2 V617F-specific guanine-quenching probe. JAK2 V617F was detected in 31 of 51 patients (60.8%) with essential thrombocythemia, all 16 patients (100%) with polycythemia vera, 4 of 11 patients (36.4%) with primary myelofibrosis, 2 of 18 patients (11.1%) with other types of MPNs, and none of the 44 patients with doubted MPN. In the 78 patients with classical MPN, JAK2 V617F correlated with a leukocyte count ≥10,000⁄μl (p=0.046). Complications of thrombosis, hemorrhage, and leukemic transformation occurred in 21 (41.2%), 4 (25.0%), and 3 (27.3%) patients with classical MPN, respectively, and thrombotic events (TE) occurred more frequently in patients with JAK2 V617F than without (p=0.047). Based on these findings, initial screening for the JAK2 mutation and careful monitoring for thrombotic events should be performed in patients with MPN.
Journal
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- The Kurume Medical Journal
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The Kurume Medical Journal 60 (3.4), 89-97, 2014
Kurume University School of Medicine