Effects of TGF-.BETA. and TGF-.BETA.-neutralizing Antibody on Normal Skin Fibroblasts and Scar-derived Fibroblasts.

DOI PubMed 被引用文献1件 オープンアクセス
  • YAMAUCHI TOSHIHIKO
    Department of Plastic and Reconstruction Surgery, Kurume University School of Medicine

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説明

Transforming growth factor-beta (TGF-β) is known as an important cytokine for scar formation in wound healing. The purpose of the present study was to investigate the effects of TGF-β and its neutralizing antibody on normal skin fibroblasts and scar-derived fibroblasts in culture. Endogenous TGF-β levels were similar in all fibroblasts. Cell proliferation increased when TGF-β1 or β2 was added to the cultures, and the increase was higher and started at a lower level in the scar-derived fibroblasts (p<0.05). The increase of fibroblasts was suppressed by the addition of TGF-β-neutralizing antibody to the cultures, and the suppression rate was higher in the scar-derived cells (p<0.05). Percentages of the cells in the growth phases of cell cycle decreased in the normal skin fibroblasts (p<0.05) when TGF-β-neutralizing antibody was added. Our findings showed that scar-derived fibroblasts and normal skin fibroblasts have a different sensitivity to TGF-β. Further study is needed on the effect of the neutralizing antibody to the cell counts and cell cycle of scarderived fibroblasts.

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詳細情報 詳細情報について

  • CRID
    1390282681322260992
  • NII論文ID
    130000882028
  • DOI
    10.2739/kurumemedj.49.171
  • ISSN
    18812090
    00235679
  • PubMed
    12652967
  • 本文言語コード
    en
  • 資料種別
    journal article
  • データソース種別
    • JaLC
    • Crossref
    • PubMed
    • CiNii Articles
    • OpenAIRE
  • 抄録ライセンスフラグ
    使用不可

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