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- 永尾 史徳
- 九州歯科大学生体機能科学専攻口腔顎顔面外科学講座病態制御学分野
書誌事項
- タイトル別名
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- Inhibitory effects of interleukin-1 receptor antagonist transfection by sonoporation on synovial cell inflammatory reactions
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抄録
Administration of an exogenous IL-1 receptor antagonist (IL-1ra) is effective for reducing inflammatory reactions mediated by IL-1. In the present study, I transfected a plasmid containing IL-1ra into synovial cells using sonoporation and investigated the anti-inflammatory effects on inflammatory reactions induced by lipopolysaccharide (LPS) in vitro. IL-1ra-transfected synovial cells produced extracellular IL-1ra, with a remarkable increase seen when the cells were cultured with LPS for 48 hr. Interestingly, though treatment with LPS enhanced the release of IL-1β in the culture supernatant of IL-1ra-transfected cells, a significant decrease of PGE2 release was observed when the cells were cultured with LPS for 60 hr. These results indicate that IL-1ra has a valuable role in regulating inflammatory reactions by synovial cells and suggest that administration of IL-1ra by sonoporation is useful for controlling inflammation due to arthritis.
収録刊行物
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- 九州歯科学会雑誌
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九州歯科学会雑誌 63 (2), 67-77, 2009
九州歯科学会
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詳細情報 詳細情報について
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- CRID
- 1390282681322698112
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- NII論文ID
- 10025993328
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- NII書誌ID
- AN00054335
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- ISSN
- 18808719
- 03686833
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- NDL書誌ID
- 10409840
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可