Fundamental Study of Inter-scanner Difference for a Multi-center Study in Brain Positron Emission Tomography

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  • Oda Keiichi
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology
  • Sakata Muneyuki
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology
  • Nishio Tomoyuki
    Division of Molecular Imaging Institute of Biomedical Research and Innovation MICRON Inc., Clinical Research Department
  • Tsushima Hiroyuki
    Osaka City University Hospital (Current address: Ibaraki Prefectural University of Health Sciences)
  • Tanizaki Yasuo
    Hamamatsu Positron Medical Center (Current address: Positron Group, Hamamatsu Medical Center)
  • Kato Seiji
    Department of Radiological Technology, The University of Tokyo Hospital
  • Ochi Shinji
    Department of Radiology, Central CI Clinic

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Other Title
  • 脳PETにおける装置差に関する基礎的研究
  • ノウ PET ニ オケル ソウチサ ニ カンスル キソテキ ケンキュウ

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Abstract

We showed scanner dependence of brain 18F-FDG and 11C-PiB images by using phantom examination with nine kinds of positron emission tomography (PET) scanners. We used two types of phantoms, cylindrical phantom with 15 cm inside diameter and three-dimensional (3D) brain phantom, and we set the body phantom on the bed to examine the effect of scatter and random coefficients from outside of the axial field of view (AFOV). Radioactivity and distance of the two phantoms were determined by a pilot study to obtain a condition similar to the clinical study. Axial uniformity was evaluated by circular region of interest (ROI) of 12 cm diameter, set in the center of the reconstruction image of the cylindrical phantom. As a result, the standardized uptake value (SUV) was lower than the true value in some scanners, and there was a scanner in which the axial uniformity was deteriorated by high radioactivity outside the AFOV. In the cylindrical phantom, the axial uniformity of the scanner was improved using the new dead-time correction method; however, it was not improved in the 3D brain phantom. Quality-controlled PET scanners are important to maintain constant levels for multicenter studies.

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