Mitochondrial effect of orally administered dibutyl phthalate in rats.

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  • フタル酸ジブチル経口投与のラット肝ミトコンドリアに及ぼす影響
  • フタル酸ジブチル経口投与のラット肝ミトコンドリアに及ぼす影響〔英文〕
  • フタルサン ジブチル ケイコウ トウヨ ノ ラット カン ミトコンドリア ニ

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Abstract

Rats fed a diet containing 5% dibutyl phthalate (DBP) for 35 to 45 days revealed growth depression, liver enlargement and testicular atrophy. These effects were accompanied by inhibited respiration in liver mitochondria. This inhibition was caused by the decrease of succinate and pyruvate dehydrogenases activities rather than by the inhibition in the other respiratory redox components, in the coupling process or in the energy-transfer process. Such inhibitory effect was also observed in vitro, where nealy the same inhibitory potency as that found in vivo, occurred at a concentration less than 100μM DBP for the respiration and 150μM DBP for the dehydrogenase activities. The present study also showed that DBP can be easily taken up into the matrix of mitochondria and that it directly affects succinate dehydrogenase without altering the transport system for succinate.

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