Exposure to Nanoparticle-Rich Diesel Exhaust May Cause Liver Damage

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  • ITO Yuki
    Department of Occupational and Environmental Health, Nagoya City University Graduate School of Medical Sciences Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine
  • RAMDHAN Doni Hikmat
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine
  • YANAGIBA Yukie
    National Institute of Occupational Safety and Health
  • YAMAGISHI Nozomi
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine
  • KAMIJIMA Michihiro
    Department of Occupational and Environmental Health, Nagoya City University Graduate School of Medical Sciences
  • NAKAJIMA Tamie
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine

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Other Title
  • ナノ粒子を多く含むディーゼル排気ガス曝露による肝臓への影響
  • ナノ リュウシ オ オオク フクム ディーゼル ハイキ ガス バクロ ニ ヨル カンゾウ エ ノ エイキョウ

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Abstract

Diesel exhaust (DE) is one of the air pollutants in the world, and exposure to DE is an environmental health concern. Most studies amongst the limited number of studies on hepatotoxicity have focused on genotoxicity or mutagenicity. However, DE exposure may cause liver damage because one prospective study suggests that DE exposure is associated with increased mortality due to arteriosclerosis and cirrhosis of the liver. Peroxisome proliferator-activated receptor (PPAR) α plays a role in the regulation of lipid homeostasis and inflammation and thereby may be involved in the progression of atherosclerosis. We investigated whether nanoparticle-rich diesel exhaust (NR-DE) affects the liver and how PPARα is involved in the NR-DE induced effects. We report these results briefly in this minireview. Our results suggest NR-DE-induced hepatic inflammation and dyslipidemia. PPARα may be involved in the development of these disorders.<br>

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