酢酸カドミウムの経口投与によるラット臓器中カドミウムの蓄積と体毛への排せつ

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  • Deposition of cadmium in organ tissues and excretion through hair following oral administration of cadmium acetate to rats.
  • サクサン カドミウム ノ ケイコウ トウヨ ニ ヨル ラット ゾウキチュウ カ

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In an attempt to evaluate hair analysis as an indicator of cadmium (Cd) deposition into organs of a population exposed to Cd in the environment via food and drinking water, an animal experiment was performed using rats.<BR>Cadmium acetate (5mg/kg/day) was orally administered using stomach tubes to two groups of male rats, each of which comprised ten in number, for three and six consecutive weeks, respectively. In place of cadmium acetate, destilled water was administered to two groups of control rats in the same manner for the same periods. At the termination of administration, all the rats were sacrificed and liver, kidney, femur, heart, spleen, lung, and blood tissues, as well as newgrown hair were dissected out. All the samples were analysed for Cd, lead (Pb), iron (Fe) and magnesium (Mg). As a result, the following findings were obtained.<BR>1) The level of Cd concentration in all the organs, including blood and hair, was significantly higher in both of the exposed groups than in the control groups, indicating that hair analysis for Cd may provide a useful monitor for the estimation of Cd deposition into organs of populations exposed to Cd via food and drinking water.<BR>2) A remarkable deterioration in Pb concentration in bone was observed after the administration of Cd to rats. Cd exposure may induce a lowering of the Pb retention threshold of bone which results in an increase of Pb in blood.<BR>3) A decrease in Fe concentration was observed in the liver, kidney, bone and spleen of rats following exposure to Cd.<BR>4) A decrease in Mg concentration was observed in the bone, lung and blood of rats after the administration of Cd.

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