書誌事項
- タイトル別名
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- Fibroblast Growth Factor 23 Mediates the Phosphaturic Actions of Cadmium
- カドミウム バクロ ニ ヨル リン タイシャ イジョウ : FGF23 サンセイ コウシン キジョ ノ ケントウ
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Phosphaturia has been documented following cadmium (Cd) exposure in both humans and experimental animals. Fibroblast growth factor 23 (FGF23) serves as an essential phosphate homeostasis pathway in the bone-kidney axis. In the present study, we investigated the effects of Cd on phosphate (Pi) homeostasis in mice. Following Cd injection into C57BL/6J mice, plasma FGF23 concentration significantly increased. The urinary Pi excretion level was significantly higher in the Cd-injected C57BL/6J mice than in the control group. Plasma Pi concentration decreased only slightly in the Cd-injected mice compared with the control group. No changes were observed in the concentration of the plasma parathyroid hormone and 1,25-dihydroxy vitamin D3 in both groups of mice. We observed a decrease in phosphate transport activity and also a decrease in the expression level of renal phosphate transporter Npt2c, but not that of Npt2a. Furthermore, we examined the effect of Cd on Npt2c in Npt2a-knockout (KO) mice, which expresses Npt2c as a major NaPi cotransporter. Injecting Cd to Npt2aKO mice induced a significant increase in plasma FGF23 concentration and urinary Pi excretion level. Furthermore, we observed decreases in phosphate transport activity and renal Npt2c expression level in the Cd-injected Npt2a KO mice. The present study suggests that hypophosphatemia induced by Cd may be closely associated with FGF23.<br>
収録刊行物
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- 日本衛生学雑誌
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日本衛生学雑誌 67 (4), 464-471, 2012
一般社団法人日本衛生学会
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詳細情報 詳細情報について
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- CRID
- 1390282681338706048
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- NII論文ID
- 10031120520
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- NII書誌ID
- AN00185923
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- COI
- 1:STN:280:DC%2BC3s%2FnvVOlsg%3D%3D
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- ISSN
- 18826482
- 00215082
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- NDL書誌ID
- 024019280
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- PubMed
- 23095356
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可