Immunological Effects of Silica/Asbestos
-
- KUMAGAI Naoko
- Department of Hygiene, Kawasaki Medical School
-
- NISHIMURA Yasumitsu
- Department of Hygiene, Kawasaki Medical School
-
- MAEDA Megumi
- Department of Hygiene, Kawasaki Medical School
-
- HAYASHI Hiroaki
- Department of Hygiene, Kawasaki Medical School
-
- OTSUKI Takemi
- Department of Hygiene, Kawasaki Medical School
Bibliographic Information
- Other Title
-
- 珪酸・アスベストの免疫影響
- ケイサン アスベスト ノ メンエキ エイキョウ
Search this article
Abstract
Silica and asbestos cause pneumoconioses known as silicosis and asbestosis, respectively, that are each characterized by progressive pulmonary fibrosis. On the other hand, silicosis patients often suffer from a type of immunological dysregulation that gives rise to autoimmunity. These epidemiological findings suggest that silica may affect the immune system in humans. In addition, as asbestos itself is a mineral silicate, it may possess generalized immunotoxicological effects similar to those associated with silica particles. Because asbestos-exposed patients are well-known to often develop malignant diseases such as lung cancer and mesothelioma, one silica-like dysregulatory outcome that needs to be considered (apart from autoimmunity) is an alteration in host tumor immunity. In this review, the immunotoxicological effects of both silica and asbestos are presented and discussed in terms of immune system dysregulation as manifested by the onset of autoimmunity or alterations in host tumor immunity.<br>
Journal
-
- Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene)
-
Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) 65 (4), 493-499, 2010
The Japanese Society for Hygiene
- Tweet
Details 詳細情報について
-
- CRID
- 1390282681338913664
-
- NII Article ID
- 10029363262
-
- NII Book ID
- AN00185923
-
- ISSN
- 18826482
- 00215082
-
- NDL BIB ID
- 10844345
-
- Text Lang
- ja
-
- Data Source
-
- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
-
- Abstract License Flag
- Disallowed