尿成分の日内変動とクレアチニン補正に関する検討

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  • Studies of Diurnal Variations and Incorporation into Creatinine Ratios in the Contents of Urine
  • ニョウ セイブン ノ ニチナイ ヘンドウ ト クレアチニン ホセイ ニ カンス

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Diurnal variations were recorded of 10 substances from the urine of 22 healthy women, ranging from 32 to 65 years of age. Twenty-four-hour urine collections were done at each micturition and blood samples were taken on the same day.<br>From the data, it was examined whether the use of creatinine ratio as a measure of the completeness of a 24-hour urine samples was reliable.<br>The results were as follows:<br>1. Maximum/minimum concentration ratios of various urinary substances were 1.2-4.6, 1.9-9.0, 1.3-11, 1.3-8.0, 1.6-12, 1.5-12, 1.7-11, 1.8-9.8, and 2.0-12, for (specific gravity-1) ×1, 000, creatinine, urea nitrogen, uric acid, calcium, inorganic phosphorus, cadmium, zinc, and copper, respectively. There were very large individual variations-2.6-78-for the ratios of urinary β2-microglobulin.<br>2. Blood urea nitrogen slightly increased with age, but other substances showed no such changes.<br>3. The mean values of each substances matched between those taken at individual micturitions and those taken over 24 hours.<br>4. Concentrations of substances in early morning urine did not always show the high levels compared with those of a 24-hour urine.<br>5. Creatinine concentrations decreased with age. For elderly women, this fact resulted the high values from correction by creatinine for the concentrations of urinary substances.<br>6. Wide diurnal variations for values corrected by specific gravity or creatinine were observed of urinary 10 substances, and such substances were inaffective in correcting urinary concentrations.<br>7. The mean specific gravity of a 24-hour urine of all subjects was 1.018. For elderly women, the value calculated by specific gravity, that is, the one multiplied by 18/(G-1)×1, 000, was more accurate than the creatinine ratio.<br>8. Urinary protein or glucose had almost no influence on specific gravity, except in the case of glucose concentrations over 500mg/dl.

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