書誌事項
- タイトル別名
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- Analysis of Environmental-Stress-Related Impairments of Inner Ear
- カンキョウ ストレス ト カンレン スル チョウカクケイ シッカン ノ カイセキ
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説明
Noise stress generated in industry is one of the environmental factors that physically affects the functions of the inner ear. Exposure to noise can cause hearing loss, resulting in serious problems in occupational and daily life. At present, however, there are very limited ways to prevent hearing impairments. The inner ear consists of the organ of Corti, vestibule and semicircular canal. Functional or morphological damage of these tissues in the inner ear caused by genetic factors, aging or environmental factors can result in hearing or balance impairments. In this review, we first introduce a deafness-related molecule found by our clinical research. Our experimental research using genetically engineered mice further demonstrated that impaired activity of the target molecule caused congenital and age-related hearing loss with neurodegeneration of spiral ganglion neurons in the inner ears. We also describe impaired balance in mice caused by exposure to low-frequency noise under experimental conditions with indoor environmental monitoring. We believe that our approaches to pursue both experimental research and fieldwork research complementarily are crucial for the development of a method for prevention of impairments of the inner ear.
収録刊行物
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- 日本衛生学雑誌
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日本衛生学雑誌 70 (2), 100-104, 2015
一般社団法人日本衛生学会
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詳細情報 詳細情報について
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- CRID
- 1390282681339111552
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- NII論文ID
- 130005070847
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- NII書誌ID
- AN00185923
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- ISSN
- 18826482
- 00215082
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- NDL書誌ID
- 026438400
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- PubMed
- 25994339
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可
