睡眠時間と酸化ストレスマーカー，尿中８‐Ｈｙｄｒｏｘｙ‐２′‐Ｄｅｏｘｙｇｕａｎｏｓｉｎｅ

DOI Web Site Web Site PubMed 被引用文献1件 参考文献34件
  • 松本 由紀
    独立行政法人労働安全衛生総合研究所産業医学総合研究所 独立行政法人労働安全衛生総合研究所産業医学総合研究所・北里大学大学院医療系研究科
  • 小川 康恭
    独立行政法人労働安全衛生総合研究所産業医学総合研究所
  • 吉田 吏江
    独立行政法人労働安全衛生総合研究所産業医学総合研究所
  • 中田 光紀
    独立行政法人労働安全衛生総合研究所産業医学総合研究所
  • 葛西 宏
    産業医科大学産業生態科学研究所
  • 大場 謙一
    北里大学大学院医療系研究科
  • 太田 久吉
    北里大学大学院医療系研究科

書誌事項

タイトル別名
  • Relationship between Length of Sleep and Oxidative Stress Marker, Urinary 8-Hydroxy-2'-Deoxyguanosine
  • スイミン ジカン ト サンカ ストレスマーカー ニョウ チュウ 8 Hydroxy 2 Deoxyguanosine

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抄録

Objectives: In this study, we aim to examine whether the length of sleep modifies the level of urinary 8-hydroxy-2'-deoxyguanosine (8-OH-dG).<br>Methods: Subjects were 146 workers who were engaged in management, clerical work, laboratory work, or business at a certain company. We obtained information on the subjects concerning gender, body mass index, drinking and smoking habits, and the lengths of habitual and previous night sleep among others using self-reported questionnaires, which were then confirmed by interview. Urine specimens were collected in the morning and those from the second or later void were used to measure 8-OH-dG and creatinine levels. The amount of 8-OH-dG normalized by creatinine content was used as the indicator of 8-OH-dG excretion (Spot Urine 8-OH-dG: SU8-OH-dG). We excluded subjects who took sleeping pills the previous night or habitually, and those whose levels were beyond the three-standard-deviation range. The subjects were then classified into three equal-sized groups according to the length of sleep, either habitual or the previous night.<br>Results and conclusion: (1) A long or a short previous night's sleep, drinking alcohol more than once a week, and habitual use of medicine increased SU8-OH-dG level among female subjects. (2) A short previous night's sleep and habitual smoking, and a short previous night's sleep and habitual use of medicine had interactions which increased SU8-OH-dG level among male subjects but the length of a previous night's sleep itself did not have an effect on SU8-OH-dG level. (3) The length of habitual sleep had no effect on SU8-OH-dG level.

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