食習慣と循環器系疾患（１）　　本邦内陸山間部および沿岸部住民における脳・心血管系疾患死亡率と血中エイコサペンタエン酸・アラキドン酸比

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  • Dietary Habits and Cardiovascular Diseases (I)
  • ショク シュウカン ト ジュンカンキケイ シッカン 1 ホンポウ ナイリク サ
  • 本邦内陸山間部および沿岸部住民における脳・心血管系疾患死亡率と血中エイコサペンタエン酸・アラキドン酸比

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It has been established that dietary habits play an impotant role in terms of the incidence of adult diseases. For example, Eskimos who eat mostly fish have an extremely low incidence of thrombotic disease in comparison to Danes who eat large amounts of meat. Dyerberg et al. reported that such differences derived from the differences in the fatty acids contained in these foods. Omoto and her study group have likewise demonstrated experimentally that fish intake can change the composition of fatty acids in blood, increase bleeding time, and inhibit the blood platelet aggregation due to arachidonic acid and collagen. To provide epidemiological data for Japan, the present authors have made studies on the fish intake for coastal and inland dwellers and determined the composition of fatty acids in their blood. The mortality rates from cerebrovascular and cardiovascular diseases were obtained from statistics by the Ministry of Welfare.<br>(1) Coastal and inland areas in Chiba-ken, Ibaraki-ken, Fukushima-ken, Iwate-ken, Niigata-ken, and Shimane-ken were selected and the standard mortality ratios (SMR) for cerebral infarction, cerebral hemorrhage, cerebral apoplexy, subarachnoid hemorrhage, and ischemic heart disease were calculated separately for men and women. It was assumed that in coastal regions the fish intake would be great and in the inland regions, significantly less. Relations between fish intake and SMR would be shown.<br>(2) With a few exceptions, the cerebral infarction, cerebral hemorrhage, subarachnoid hemorrhage, and cerebral apoplexy SMRs were lower for both males and females in coastal than in inland areas. <br>(3) The ischemic heart disease SMR was lower in inland areas for males in three prefectures surveyed and for females in two prefectures.<br>(4) Fish intake and the composition of fatty acids in blood were calculated for persons in three prefectures. The fish intake was very low for the inland-dwellers and that for the coast-dwellers was very high giving a large difference between two areas in terms of fatty acid composition. Eicosapentaenoic acid content was very high in the coastal group.<br>(5) In the case of cerebrovascular diseases, there was a significant negative correlation between each SMR and fish-eating population.

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