Toxicity of dibutyl phthalate and its metabolites in rats.

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  • フタル酸ジブチルおよびその代謝物の毒性に関する研究
  • フタル酸ジブチルおよびその代謝物の毒性に関する研究〔英文〕
  • フタルサン ジブチル オヨビ ソノ タイシャブツ ノ ドクセイ ニ カンスル

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Rats were given a powder diet containing dibutyl phthalate (DBP), monobutyl phthalate (MBP), di-2-ethylhexyl phthalate (DEHP) or phthalic acid (PA) at a level of 0.5 or 5% for 34 to 36 days, respectively. The rats treated with a 5% diet of DBP, MBP or DEHP revealed growth depression, liver enlargement, testicular atrophy, decreased activities of succinate and pyruvate dehydrogenases in liver mitochondria, and abnormal changes in biochemical tests of serum and in histological examinations of the liver and testicle. These adverse effects were also observed in rats fed a 0.5% diet of these compounds, although they were less severe. On the other hand, PA had no effect, even at a 5% concentration in the diet.<br>The changes in hepatocellular ultrastructure were more prominent in rats treated with DBP than in those given MBP. The most striking difference between DBP and MBP was that DBP showed a potent inhibitory effect on succinate dehydrogenase activity in liver mitochondria in vitro, wherease MBP showed no such effect. This difference was also observed in liver mitochondrial respiration in vitro.<br>It was suggested that the adverse effects of orally administered DBP at least on the liver may be caused partly by the direct action of intact DBP entering the liver.

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