定量的ＰＥＴ測定に用いる測定器の信頼性‐電離箱式放射能測定装置，ウェル型シンチレーションカウンタ，持続動脈血中放射能濃度測定器およびＰＥＴ装置の評価‐

DOI Web Site PubMed 被引用文献3件 参考文献21件
  • 松本 圭一
    京都医療科学大学医療科学部 大阪大学大学院医学系研究科保健学専攻医用物理工学講座 独立行政法人理化学研究所分子イメージング研究プログラム
  • 山本 誠一
    神戸市立工業高等専門学校電気工学科
  • 和田 康弘
    独立行政法人理化学研究所分子イメージング研究プログラム
  • 清水 敬二
    先端医療センター分子イメージング研究グループ
  • 村瀬 研也
    大阪大学大学院医学系研究科保健学専攻医用物理工学講座
  • 千田 道雄
    先端医療センター分子イメージング研究グループ

書誌事項

タイトル別名
  • Reliability of Plural Measuring Instruments for Quantitative PET Measurement -Performance of Dose-calibrator, Auto Well Gamma Counter, Continuous Blood Sampling System, and PET Scanner-
  • 定量的PET測定に用いる測定器の信頼性--電離箱式放射能測定装置,ウェル型シンチレーションカウンタ,持続動脈血中放射能濃度測定器およびPET装置の評価
  • テイリョウテキ PET ソクテイ ニ モチイル ソクテイキ ノ シンライセイ デンリバコシキ ホウシャノウ ソクテイ ソウチ ウェルガタ シンチレーション カウンタ ジゾク ドウミャク ケッチュウ ホウシャノウ ノウド ソクテイキ オヨビ PET ソウチ ノ ヒョウカ

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Purpose: Positron emission tomography (PET) is a powerful tool for measuring in vivo functions such as blood flow, metabolism, enzyme activity, receptors, and transporters. However, plural measuring instruments (i.e., the dose-calibrator, the auto well gamma counter, the continuous blood sampling system) are necessary for the quantitative PET measurement as well as the PET scanner. The purpose of this study was to investigate the reliability of plural measuring instruments from the maintenance data for 6 years. Methods: Four kinds of measuring instrument were evaluated: a dose-calibrator (CAPINTEC, CRC-15R), an auto well gamma counter (ALOKA, ARC-400), a continuous blood sampling system (ESPEC Techno, PH type), and a dedicated PET scanner (Siemens, ECAT EXACT HR+). We examined whether the initial performance for system sensitivity is maintained. The reliability of the PET scanner was evaluated from the value of mean time between failures (MTBF) for each part of the system obtained from the maintenance data for 6 years. Results: The sensitivity of a dose-calibrator and an auto well gamma counter were maintained virtually constant during the 6 years, but the sensitivity of a continuous blood sampling system was 0.1±3.2%. The sensitivity of a PET scanner was decreased to 92.3% of the initial value. Fifty-one percent of the problems with the PET scanner were for detector block (DB) and analog processor (AP) board. The MTBF of DB and AP board module were 199 and 244 days, respectively. The MTBF of the PET scanner was 56 days. Conclusion: The performance of three measuring instruments, excepting the PET scanner, was relatively stable. The reliability of the PET scanner strongly depends on the MTBF of the DB and AP board. For quantitative PET measurement, it is effective to evaluate the reliability of the system and to make it known to the users.

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