二硫化炭素注射家兎の銅代謝に関する実験的研究

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  • An Experimental Study on Copper Metabolism in the Carbon Disulfide Poisoned Rabbits
  • 2リュウカ タンソ チュウシャ カト ノ ドウ タイシャ ニ カンスル ジッケンテキ ケンキュウ

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It has been recognized that CS2, when injected to laboratory animal, may combine with a group of amino acids and protein in serum to forming thiocarbamate and thiazolidone, which are known to be a chelating agent, and might, therefore, affect trace metal metabolism in the animal body. In this experiment, by repeated subcutaneous injections of CS2 to rabbits, body weight, hematocrit, hemoglobin, serum copper, serum caeruloplasmin, urinary copper and, serum and urinary iron were observed sequentially for 368 experimental days. Rabbits were divided three groups of three animals each; first group was injected olive oil 2-diluted CS2 0.8cc per 10 days, second group 0.4cc per 10 days, and control group was given olive oil alone. Results obtained are as follows:<br>1. Neither CS2 rabbits nor cotrol showed loss of body weight through the whole period of the experiment (Fig. 1).<br>2. Hematocrit and hemoglobin of the CS2 rabbits showed lower values than the control at the later period of the experiment (Fig. 2, 3).<br>3. Marked decrease of serum copper concentration was observed in the first and second groups according to repeated injections of CS2 as shown in Fig. 4. After 6 months recess of CS2 administration, however, this copper values were gradually recovered to a preexpeimental level. Serum caeruloplasmin, a copper enzyme bound to serum ∝-globuline, showed on meaningful change. It may, therefore, be suggested that the decreased serum copper would probably be derived from free copper faction in the blood. Increased excretion of copper in urine was noted as shown in Fig. 6; concentration curve of urinary copper showed the adverse parallelism with serum copper. Behavior of serum and urinary iron in the CS2animals was identical to of copper.<br>Based on these findings, it may be concluded that a chelating compound would be formed in the blood when CS2 is administered and this agent would affect the body metal metabolism by acting as a secondary metabolite toxin.

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