流行性耳下腺炎の血清疫学的研究

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タイトル別名
  • Sero-epidemiological studies of mumps
  • リュウコウセイ ジカセンエン ノ ケッセイエキガクテキ ケンキュウ 3
  • III. Reconsideration on the epidemiological significance of Hemagglutination-inhibiting and complement-fixing antibodies to mumps virus
  • 第3報 HI及びCF抗体の疫学的意義の再検討

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The present paper concerns with evaluation of antibodies in human sera as the indices of susceptibility to and infection with mumps in epidemiological study of the disease. School children exposed to a severe epidemic of mumps were subjected to the study. The results obtained are as follows:<br>1) No case of clinical mumps was observed among the children who had possessed CF antibody before epidemic, irrespective to whether they had possessed HI antibody at the same time or not. In contrast, not a few apparent cases occured in those who had not possessed CF antibody but HI antibody. This result means that CF antibody in sera would play a decisive role in the prevention of clinical attack of mumps.<br>2) About 20% of the childred showed no rise of CF antibody in titer until the epidemic ended. The percentage negatives of the antibody were closely similar among each school class, although the attack rates were differed significantly from class to class.<br>3) The rise of HI antibody in titer was much greater in the group of children which devoided of CF antibody than in that having possessed CF antibody at the initial time. The same difference was observed even when clinical cases were excluded from the former group and then compared with the latter.

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