An experimental study on the influence of milk aspiration on bronchial reactivity to cigarette smoke in guinea pigs.

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  • シガレット煙に対するモルモットの気道反応性の経気管的ミルク注入による影響
  • シガレット煙に対するモルモットの気道反応性の経気管的ミルク注入による影響〔英文〕
  • シガレット ケムリ ニ タイスル モル

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Guinea pigs inoculated intratracheally with cow's milk in infancy (milk-inoculated group), which were designed as a model of the aspiration of milk formulae in bottle-fed infants, were exposed to cigarette smoke to investigate their respiratory response. Guinea pigs received physiological saline instead of cow's milk were also exposed to the smoke as a control (saline-inoculated group). After exposure for a period of five months, dyspnea was observed immediately after smoking, with an incidence of 63.6% in the milk-inoculated group and 33.3% in the saline-inoculated one. The ratio of the respiratory rate after exposure to that before exposure was 72.7% in the former group and 85.2% in the latter group, which suggested that the intensity of dyspnea in the milk-inoculated group was higher than in the saline-inoculated one. Although histaminase activity in blood plasma of the former group was 1.7 times greater than that of the latter, histamine content in the lung was lower in the former. The coefficient of beat-to-beat variation was larger in the former. It was revealed from these results that high vagal tone and the histamine release from the lung induced by smoking were present in the milk-inoculated group. Consequently, the aspiration of cow's milk in infancy appears to be able to alter the reactivity of the airways, making them hypersensitive to cigarette smoke.

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