Dynamic Contrast-enhanced T_1 Measuring MRI Using Variable Flip Angle SPGR

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  • ISHIMORI YOSHIYUKI
    Radiological Center, Fukui Medical University Hospital:(Present address)Radiological Center, Fukui University Hospital
  • KIMURA HIROHIKO
    Department of Radiology, Fukui Medical University:(Present address)Faculty of Medical Sciences, University of Fukui
  • MATSUDA TSUYOSHI
    Imaging Application Tech Center, GE Yokogawa Medical Systems, Co., Ltd.
  • UEMATSU HIDEMASA
    Department of Radiology, Fukui Medical University:(Present address)Faculty of Medical Sciences, University of Fukui
  • ISHIDA TOMOKAZU
    Radiological Center, Fukui Medical University Hospital:(Present address)Radiological Center, Fukui University Hospital
  • FUKUYA YUKO
    Radiological Center, Fukui Medical University Hospital:(Present address)Radiological Center, Fukui University Hospital
  • KITA AKINOBU
    Radiological Center, Fukui Medical University Hospital:(Present address)Radiological Center, Fukui University Hospital

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Other Title
  • 可変Flip Angle SPGRによる造影ダイナミックT<sub>1</sub>値計測MRI

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Description

We modified the multi-phase spoiled gradient recalled echo (SPGR.) pulse sequence using the double-echo MR technique for estimation of T_1 during the first pass of contrast agent, and examined its precision. In the first half of the pulse sequence, the flip angle was varied systematically to calculate static T_1 values. It was necessary to choose optimal flip angles to minimize the calculation error of static T_1 values. In the latter half of this sequence, changes in absolute T_1 were calculated using differences in signal intensities before and after the injection of contrast agent. The optimal flip angle was 20 degrees for precise conversion to T_1 values under the short TR(33.3 ms)condition. Double echo MR data were used to minimize the T_2 effect. The present method appears to be useful for quantitative estimation of dynamic contrast-enhanced MRI.

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