書誌事項
- タイトル別名
-
- Investigation of endogenous prostaglandins on DMH induced colonic cancer in rats.
抄録
Chemical carcinogen, DMH was administered subcutaneously in rats to investigate the relation between prostaglandins (PGs) and colonic cancer. PGE levels in the colonic mucosa of control group were 40.2±3.4 (ng/g wet weight). But, PGE levels in the colonic mucosa of DMH group were significantly higher (49.5±2.4) than that of control group (p<0.05). PGE levels in colonic cancer of DMH group were also significantly high (54.1±4.9) compared with that in the colonic mucosa of control group (p<0.05). On the other hand, PGF2αlevels in the colonic mucosa of control group were 34.7±3.7. PGF2α levels in colonic cancer of DMH group were significantly low (17.6±2.1) compared with that in the colonic mucosa of control group (p<0.005) and that in the colonic mucosa of DMH group (p<0.01). Moreover, E/F2α ratios in colonic cancer of DMH group were significantly high compared with that in the colonic mucosa of control group (p<0.001) and DMH group (p<0.001).<br>It was suggested that PGs are concerned in carcinogenesis and proliferation of colonic cancer in rats.
収録刊行物
-
- 日本消化器病学会雑誌
-
日本消化器病学会雑誌 82 (4), 592-598, 1985
一般財団法人 日本消化器病学会