DMH誘発ラット大腸がんにおける内因性プロスタグランディンの検討

書誌事項

タイトル別名
  • Investigation of endogenous prostaglandins on DMH induced colonic cancer in rats.

抄録

Chemical carcinogen, DMH was administered subcutaneously in rats to investigate the relation between prostaglandins (PGs) and colonic cancer. PGE levels in the colonic mucosa of control group were 40.2±3.4 (ng/g wet weight). But, PGE levels in the colonic mucosa of DMH group were significantly higher (49.5±2.4) than that of control group (p<0.05). PGE levels in colonic cancer of DMH group were also significantly high (54.1±4.9) compared with that in the colonic mucosa of control group (p<0.05). On the other hand, PGFlevels in the colonic mucosa of control group were 34.7±3.7. PGF levels in colonic cancer of DMH group were significantly low (17.6±2.1) compared with that in the colonic mucosa of control group (p<0.005) and that in the colonic mucosa of DMH group (p<0.01). Moreover, E/F ratios in colonic cancer of DMH group were significantly high compared with that in the colonic mucosa of control group (p<0.001) and DMH group (p<0.001).<br>It was suggested that PGs are concerned in carcinogenesis and proliferation of colonic cancer in rats.

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キーワード

詳細情報 詳細情報について

  • CRID
    1390282681370994304
  • NII論文ID
    130001064414
  • DOI
    10.11405/nisshoshi1964.82.592
  • COI
    1:CAS:528:DyaL2MXkvVeiu7g%3D
  • ISSN
    13497693
    04466586
  • PubMed
    4021163
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • PubMed
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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