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- TANAKA Masato
- 2nd Department of Internal Medicine, Nagoya University School of Medicine
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- NAKAZAWA Saburou
- 2nd Department of Internal Medicine, Nagoya University School of Medicine
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- KOIKE Mitsumasa
- 2nd Department of Internal Medicine, Nagoya University School of Medicine
Bibliographic Information
- Other Title
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- ＤＭＨ誘発ラット大腸がんにおける内因性プロスタグランディンの検討
Abstract
Chemical carcinogen, DMH was administered subcutaneously in rats to investigate the relation between prostaglandins (PGs) and colonic cancer. PGE levels in the colonic mucosa of control group were 40.2±3.4 (ng/g wet weight). But, PGE levels in the colonic mucosa of DMH group were significantly higher (49.5±2.4) than that of control group (p<0.05). PGE levels in colonic cancer of DMH group were also significantly high (54.1±4.9) compared with that in the colonic mucosa of control group (p<0.05). On the other hand, PGF2αlevels in the colonic mucosa of control group were 34.7±3.7. PGF2α levels in colonic cancer of DMH group were significantly low (17.6±2.1) compared with that in the colonic mucosa of control group (p<0.005) and that in the colonic mucosa of DMH group (p<0.01). Moreover, E/F2α ratios in colonic cancer of DMH group were significantly high compared with that in the colonic mucosa of control group (p<0.001) and DMH group (p<0.001).<br>It was suggested that PGs are concerned in carcinogenesis and proliferation of colonic cancer in rats.
Journal
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- Nippon Shokakibyo Gakkai Zasshi
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Nippon Shokakibyo Gakkai Zasshi 82 (4), 592-598, 1985
The Japanese Society of Gastroenterology