The Expression of c-MET/Hepatocyte Growth Factor receptor in Colorectal Cancer.

DOI PubMed 3 Citations 17 References
  • AJISAKA Hideyuki
    Second Department of Surgery, Kanazawa University School of Medicine
  • NISHIMURA Gen-ichi
    Second Department of Surgery, Kanazawa University School of Medicine
  • TSUNEDA Atsushi
    Second Department of Surgery, Kanazawa University School of Medicine
  • FUJITA Hideto
    Second Department of Surgery, Kanazawa University School of Medicine
  • MICHIWA Yoshio
    Second Department of Surgery, Kanazawa University School of Medicine
  • KAWAMURA Taiichi
    Second Department of Surgery, Kanazawa University School of Medicine
  • SATO Takahiro
    Second Department of Surgery, Kanazawa University School of Medicine
  • NOJIMA Naomi
    Second Department of Surgery, Kanazawa University School of Medicine
  • FUSHIDA Sachio
    Second Department of Surgery, Kanazawa University School of Medicine
  • FUJIMURA Takashi
    Second Department of Surgery, Kanazawa University School of Medicine
  • YONEMURA Yutaka
    Second Department of Surgery, Kanazawa University School of Medicine
  • MIWA Koichi
    Second Department of Surgery, Kanazawa University School of Medicine

Bibliographic Information

Other Title
  • 大腸癌におけるｃ‐ＭＥＴ／Ｈｅｐａｔｏｃｙｔｅ　Ｇｒｏｗｔｈ　Ｆａｃｔｏｒ　Ｒｅｃｅｐｔｏｒの発現

Search this article

Description

In this study, we estimated the expression of c-MET/Hepatocyte Growth Factor receptor in colorectal cancers by immunohistochemistory. In 118 patients, c-MET were expressed in 65 patients (55%). About the clinicopathological findings of metastasis, the proportion of c-MET-positive in the patients with liver metastasis, 78% (18/23), was significantly higher than that without liver metastasis, 49% (47/95), but there was no significant difference about lymph node metastasis and peritoneal dissemination. About the pathological findings of primary lesion, the proportion of c-MET-positive in the patients with infiltration into lymphatic vessels, 63% (48/76), was significantly higher than that without infiltration, 40% (17/42), but there was no significant difference about infiltration into veins. The proportion of c-MET-positive increased as the tumor stage proceeded from t1 to t4 and as the histopathological stage proceeded from I to IV. These results suggest that c-MET may play an important role in the growth and scattering of colorectal cancer cells.

Journal

Citations (3)*help

See more

References(17)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top