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- SATOH Hiroshi
- The Third Department of Internal Medicine, Osaka City University Medical School
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- ARAKAWA Tetsuo
- The Third Department of Internal Medicine, Osaka City University Medical School
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- FUKUDA Takashi
- The Third Department of Internal Medicine, Osaka City University Medical School
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- HIGUCHI Kazuhide
- The Third Department of Internal Medicine, Osaka City University Medical School
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- NAKAMURA Hajime
- The Third Department of Internal Medicine, Osaka City University Medical School
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- CHONO Shinji
- The Third Department of Internal Medicine, Osaka City University Medical School
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- YAMADA Hiroaki
- The Third Department of Internal Medicine, Osaka City University Medical School
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- ONO Tokio
- The Third Department of Internal Medicine, Osaka City University Medical School
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- KOBAYASHI Kenzo
- The Third Department of Internal Medicine, Osaka City University Medical School
Bibliographic Information
- Other Title
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- ラット胃粘膜Ｐｒｏｓｔａｇｌａｎｄｉｎｓに関する研究 ＩＸ センナによる影響
- センナによる影響
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Description
We investigated the effect of senna, one of the laxatives, on the levels of prostaglandins (PG) in the rat gastric mucosa. Intragastric (i.g.) instillation of senna (3mg/kg) increased PGE2 by 3.6 times (p<0.025), PGI2 by 3.7 times (p<0.01), TXA2 by 2.8 times (p<0.01), in the fundic mucosa; PGE2 by 2.9 times (p<0.01), PGI2 by 3.4 times (P<0.025), TXA2 by 1.5 times (N.S.) in the antral mucosa.<br>High dose of senna (300mg/kg, i.g.) also increased PG levels dose-independently. I.g. instillation of senna (300mg/kg) inhibited the gastric lesions induced by the necrotizing agent (0.6N HCl)-the ulcer index, 10.0±8.3; significantly different at p<0.05 from controls indicating the ulcer index at 49.2± 12.1-. These results suggest that the cytoprotective effect of senna is mediated by the endogenous PG in the gastric mucosa.
Journal
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- Nippon Shokakibyo Gakkai Zasshi
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Nippon Shokakibyo Gakkai Zasshi 81 (3), 825-828, 1984
The Japanese Society of Gastroenterology