A case of autoimmune hepatitis which worsened after switching from a brand name to a generic version of prednisolone

DOI 14 References
  • KAKIZAKI Satoru
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
  • SUZUKI Hideyuki
    Department of Internal Medicine, Haramachi Red Cross Hospital
  • ICHIKAWA Takeshi
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
  • SATO Ken
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
  • TAKAGI Hitoshi
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
  • MORI Masatomo
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
  • YUASA Keiichiro
    Department of Internal Medicine, Yuasa Clinic

Bibliographic Information

Other Title
  • プレドニゾロンのジェネリック医薬品への変更により増悪した自己免疫性肝炎の1例

Search this article

Description

We recently encountered a case of autoimmune hepatitis whose symptoms worsened after switching from a brand name to a generic version of prednisolone. The patient was a 46-year-old woman. She was admitted because of elevation of alanine aminotransferase (ALT) levels during follow-up sessions. We diagnosed worsening of autoimmune hepatitis and increased the medication dose of prednisolone, which resulted in a quick normalization of serum ALT levels. When the prednisolone medication was switched from a brand name to a generic version, the serum ALT levels again increased. We concluded that switching from a brand name to generic version of the drug was one of reasons for the elevation in the serum ALT levels. Although most generic drugs are considered to be useful, it is important to carefully observe patients to confirm that an equivalent effect is obtained after switching from a brand name to a generic drug.<br>

Journal

References(14)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top