A case of 5-fluorouracil-induced hyperammmonia after chemotherapy for metastatic colon cancer

DOI PubMed 7 Citations 25 References
  • NAKAMURA Masamoto
    Department of Internal Medicine, Okinawa Red Cross Hospital
  • KOBASHIKAWA Kasen
    Department of Internal Medicine, Okinawa Red Cross Hospital
  • TAMURA Jiro
    Department of Internal Medicine, Okinawa Red Cross Hospital
  • TAKAKI Ryo
    Department of Internal Medicine, Okinawa Red Cross Hospital
  • OHSHIRO Masaru
    Department of Internal Medicine, Okinawa Red Cross Hospital
  • MATAYOSHI Ryoji
    Department of Internal Medicine, Okinawa Red Cross Hospital Matayoshi Clinic
  • HIRATA Tetsuo
    First Department of Internal Medicine, Ryukyu University Hospital, Faculty of Medicine, University of The Ryukyus
  • KINJYO Fukunori
    Department of Endoscopy, Ryukyu University Hospital, Faculty of Medicine, University of The Ryukyus
  • FUJITA Jiro
    First Department of Internal Medicine, Ryukyu University Hospital, Faculty of Medicine, University of The Ryukyus

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  • mFOLFOX6療法中に高アンモニア血症による意識障害を認めた切除不能大腸癌の1例

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Abstract

A 79-year-old woman with colon cancer and multiple liver metastases was admitted to our hospital for systemic chemotherapy. She underwent first cycle of modified FOLFOX6 chemotherapy. She was confused on treatment day 5. Blood test revealed her serum ammonia level to be 121 μg/dl. We diagnosed 5-fluorouracil (5FU)-induced hyperammonemia. Conservative treatment resulted in improvement of metal status. The reason for hyperammonemia after administration of 5FU was the excess production of ammonium from metabolites of 5FU.<br>

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