A case of 5-fluorouracil-induced hyperammmonia after chemotherapy for metastatic colon cancer
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- NAKAMURA Masamoto
- Department of Internal Medicine, Okinawa Red Cross Hospital
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- KOBASHIKAWA Kasen
- Department of Internal Medicine, Okinawa Red Cross Hospital
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- TAMURA Jiro
- Department of Internal Medicine, Okinawa Red Cross Hospital
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- TAKAKI Ryo
- Department of Internal Medicine, Okinawa Red Cross Hospital
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- OHSHIRO Masaru
- Department of Internal Medicine, Okinawa Red Cross Hospital
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- MATAYOSHI Ryoji
- Department of Internal Medicine, Okinawa Red Cross Hospital Matayoshi Clinic
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- HIRATA Tetsuo
- First Department of Internal Medicine, Ryukyu University Hospital, Faculty of Medicine, University of The Ryukyus
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- KINJYO Fukunori
- Department of Endoscopy, Ryukyu University Hospital, Faculty of Medicine, University of The Ryukyus
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- FUJITA Jiro
- First Department of Internal Medicine, Ryukyu University Hospital, Faculty of Medicine, University of The Ryukyus
Bibliographic Information
- Other Title
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- mFOLFOX6療法中に高アンモニア血症による意識障害を認めた切除不能大腸癌の1例
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Description
A 79-year-old woman with colon cancer and multiple liver metastases was admitted to our hospital for systemic chemotherapy. She underwent first cycle of modified FOLFOX6 chemotherapy. She was confused on treatment day 5. Blood test revealed her serum ammonia level to be 121 μg/dl. We diagnosed 5-fluorouracil (5FU)-induced hyperammonemia. Conservative treatment resulted in improvement of metal status. The reason for hyperammonemia after administration of 5FU was the excess production of ammonium from metabolites of 5FU.<br>
Journal
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- Nippon Shokakibyo Gakkai Zasshi
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Nippon Shokakibyo Gakkai Zasshi 106 (12), 1744-1750, 2009
The Japanese Society of Gastroenterology
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Keywords
Details 詳細情報について
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- CRID
- 1390282681376723200
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- NII Article ID
- 10026134507
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- NII Book ID
- AN00192124
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- COI
- 1:STN:280:DC%2BD1MfgvVWmug%3D%3D
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- ISSN
- 13497693
- 04466586
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- PubMed
- 19966516
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- Text Lang
- ja
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- Data Source
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- JaLC
- PubMed
- CiNii Articles
- Crossref
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- Abstract License Flag
- Disallowed