A case of diffuse esophageal spasm successfully treated by steroid therapy

  • FUNAKI Yasushi
    Division of Gastroenterology, Department of Internal Medicine, Aichi Medical University School of Medicine Division of Laboratory Medicine, Aichi Medical University Hospital
  • IIDA Akihito
    Division of Gastroenterology, Department of Internal Medicine, Aichi Medical University School of Medicine
  • SHIMOZATO Akihiro
    Division of Gastroenterology, Department of Internal Medicine, Aichi Medical University School of Medicine
  • YAMAGUCHI Junji
    Division of Gastroenterology, Department of Internal Medicine, Aichi Medical University School of Medicine
  • TANABE Atsushi
    Division of Gastroenterology, Department of Internal Medicine, Aichi Medical University School of Medicine
  • TAMURA Yasuhiro
    Division of Gastroenterology, Department of Internal Medicine, Aichi Medical University School of Medicine
  • IZAWA Shinya
    Division of Gastroenterology, Department of Internal Medicine, Aichi Medical University School of Medicine
  • OGASAWARA Naotaka
    Division of Gastroenterology, Department of Internal Medicine, Aichi Medical University School of Medicine
  • SASAKI Makoto
    Division of Gastroenterology, Department of Internal Medicine, Aichi Medical University School of Medicine
  • KASUGAI Kunio
    Division of Gastroenterology, Department of Internal Medicine, Aichi Medical University School of Medicine

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Other Title
  • ステロイド治療が有効であったびまん性食道痙攣症の1例

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Description

A 53-year-old man was admitted to our hospital with anterior chest pain and difficulty swallowing. Computed tomography revealed significant esophageal wall thickening. Esophageal intraluminal manometry revealed uncoordinated contraction and strong peristaltic pressure associated with the chest pain. The patient was subsequently diagnosed with diffuse esophageal spasm (DES). His serum immunoglobulin E level was high, and peripheral blood eosinophilia was observed. No eosinophilic infiltration was detected in the esophageal mucosa on endoscopic biopsy. It was presumed that this case of DES was induced by allergic disease. Treatment with 30 mg of oral prednisolone led to a prompt resolution of symptoms;the thickness of the esophageal wall decreased, and the simultaneous contractions disappeared. However, given the presence of a strong peristaltic wave, nutcracker esophagus (NE) was also suspected. This was a rare case of atypical DES induced by allergic disease and associated with NE.

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