Intrahepatic cholangiocarcinoma producing granulocyte colony-stimulating factor and parathyroid hormone-related protein
-
- OZAWA Noritaka
- Department of Gastroenterology, Teikyo University Mizonoguchi Hospital
-
- DOI Shinpei
- Department of Gastroenterology, Teikyo University Mizonoguchi Hospital
-
- TSUJIKAWA Takayuki
- Department of Gastroenterology, Teikyo University Mizonoguchi Hospital
-
- MABUCHI Masatoshi
- Department of Gastroenterology, Teikyo University Mizonoguchi Hospital
-
- KAJIYAMA Yusuke
- Department of Gastroenterology, Teikyo University Mizonoguchi Hospital
-
- SATO Koichiro
- Department of Gastroenterology, Teikyo University Mizonoguchi Hospital
-
- KIKUCHI Kentaro
- Fourth Department of Internal Medicine, Teikyo University Mizonoguchi Hospital
-
- TAKAHASHI Mikiko
- Department of Clinical Pathology, Teikyo University Mizonoguchi Hospital
-
- KAWAMOTO Masashi
- Department of Clinical Pathology, Teikyo University Mizonoguchi Hospital
-
- YASUDA Ichiro
- Department of Gastroenterology, Teikyo University Mizonoguchi Hospital
Bibliographic Information
- Other Title
-
- G-CSF＋PTHrP産生肝内胆管癌の1例
Search this article
Abstract
<p>A 78-year-old man was referred to our hospital with suspected liver abscess. Fever and inflammatory reaction resolved after percutaneous drainage and administration of antibiotics. However, leukocyte count was remarkably increased, and hypercalcemia was noted. The liver mass was also enlarged, as observed in the follow-up abdominal CT scans. Therefore, a percutaneous needle biopsy was performed, and the histopathological findings indicated the presence of adenocarcinoma. Additional blood examination revealed high serum levels of granulocyte colony-stimulating factor (G-CSF) and parathyroid hormone-related protein (PTHrP). Lastly, the patient was diagnosed with cholangiocarcinoma producing G-CSF and PTHrP. Chemoradiotherapy with S-1 was initiated, which was partially effective. However, the patient died 134 days after initiating the therapy. Only two cases of cholangiocarcinoma producing G-CSF and PTHrP have been reported to date. Here we reported an additional case of cholangiocarcinoma producing G-CSF and PTHrP.</p>
Journal
-
- Nippon Shokakibyo Gakkai Zasshi
-
Nippon Shokakibyo Gakkai Zasshi 114 (7), 1285-1292, 2017
The Japanese Society of Gastroenterology