味噌中のメラニン生成抑制物質の同定

DOI Web Site 被引用文献3件 参考文献12件

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タイトル別名
  • Purification and Identification of Melanogenesis Inhibitory Factors in Miso.
  • ミソ ノ メラニン セイセイ ヨクセイ ブッシツ

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説明

In the previous paper, we reported that an extract from miso strongly suppressed melanogenesis of B16C7 melanoma cells. In this paper, we purified two melanogenesis suppressing materials. The materials were identified to be linoleic acid and ethyl linoleate by mass spectrometric analysis. Synthesis of tyrosinase, a key enzyme on melanogenesis, of B16C7 melanoma cells was strongly suppressed by addition of linoleic acid to a culture medium, whereas linoleic acid did not inhibit the activity of partially purified tyrosinase from B16C7 melanoma cells.

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