Safety Evaluation of Excessive Intake of Calcium-fortified Fish Sausage to Prevent Osteoporosis in Humans

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  • 骨粗鬆症予防を目的としたカルシウム強化ソーセージの過剰摂取時の安全性評価
  • コツソショウショウ ヨボウ オ モクテキ ト シタ カルシウム キョウカ ソーセージ ノ カジョウ セッシュジ ノ アンゼンセイ ヒョウカ

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Abstract

This study attempted to clarify the safety of excessive intake (400mg) of calcium-fortified fish sausage, a special health food in Japan, in the prevention of osteoporosis. Safety was evaluated based on an open-label human trial in which 20 healthy subjects took 3 times the recommend amount of fish sausages a day for 4 weeks. Adverse events were assessed, and physical measurements, laboratory assessment and nutrition were analyzed. During the 4-week safety evaluation, no clinical changes were found in any of the subjects. Thus the daily intake of fish sausage appears to be safe as a means to obtain the daily requirements of calcium.

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