Effects of Millet Grain Administration on Lipid Metabolism in Type 2 Diabetic db/db Mice
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- Watanabe Mitsuru
- National Agricultural Research Center for Tohoku Region
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- Kato Masako
- National Agricultural Research Center for Tohoku Region
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- Ayugase Jun
- National Agricultural Research Center for Tohoku Region
Bibliographic Information
- Other Title
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- 2型糖尿病db/dbマウスの脂質代謝に及ぼす雑穀の効果
- 2ガタ トウニョウビョウ db db マウス ノ シシツ タイシャ ニ オヨボス ザッコク ノ コウカ
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Abstract
We investigated the effects of an oral administration of daily millet grain feed in type 2 diabetic mice. Mice (C57BL/KsJ-leprdb/leprdb, db/db) were fed a diet containing 20% proso millet (PM) , Japanese barnyard millet (BM) , or adlay (AD) powder based on AIN-93G for 21 days. As a result, the HbA1c concentration of whole blood was lower in the diabetic PM- and BM-fed groups than in the diabetic control (AIN-93G) group. Concentrations of hepatic lipid parameters, such as lipids, total cholesterol, and triglycerides in the BM- and AD-fed groups were lower than those in the diabetic control group. In addition, the concentration of bile acid in feces was higher in the diabetic BM- and AD-fed groups than in the diabetic control group. Although gene expression of cholesterol synthesis enzymes such as 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoAR) was not different between the diabetic mice groups, that of bile acid synthesis enzymes such as cholesterol 7 α-hydroxylase (CYP7A1) was higher in the diabetic BM- and AD-fed groups than in the diabetic control group. These results suggest that PM and BM grains have hypoglycemic activity, and BM and AD grains have hypolipidemic activity. The effect of improved lipid metabolism by BM and AD grains is attributed to the acceleration of bile acid synthesis in liver along with its excretion into feces.
Journal
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- Nippon Shokuhin Kagaku Kogaku Kaishi
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Nippon Shokuhin Kagaku Kogaku Kaishi 58 (10), 476-482, 2011
Japanese Society for Food Science and Technology
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Details 詳細情報について
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- CRID
- 1390282681384227328
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- NII Article ID
- 10029839135
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- NII Book ID
- AN10467499
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- ISSN
- 18816681
- 1341027X
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- NDL BIB ID
- 11268703
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- Text Lang
- ja
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- Data Source
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- JaLC
- IRDB
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed