The Suppressive Effect of Protamine from Chum Salmon Milt on Lipid Absorption in Humans

DOI Web Site 1 Citations 22 References

Bibliographic Information

Other Title
  • サケ由来プロタミンの脂質吸収抑制効果
  • サケ ユライ プロタミン ノ シシツ キュウシュウ ヨクセイ コウカ

Search this article

Description

Protamine is a basic protein that is combined with DNA in the vertebrate sperm nucleus. It was reported that protamine purified from chum salmon milt has pancreas lipase inhibition activity (IC50=1.2μg/mL). In the case of rats, protamine administration (100mg/rat) showed a suppressive effect on the blood plasma triglyceride (TG) levels in the corn oil tolerance test. Here, we investigated the suppressive effect of our developed protamine, “Proserve”, on lipid absorption in humans.<BR>The oral fat tolerance test (OFTT) was performed on normal adult male subjects as a single-blind test. The subjects were fed a high-fat meal containing 56.0g of lipid and 500mg of protamine. Before and 2, 3, 4, 6h after ingestion, TG and free fatty acid levels in blood were measured. Protamine significantly suppressed the elevations of the TG and free fatty acid levels in blood after ingestion of the high fat meal compared with the placebo group. When 300mg of protamine was administered, no significant suppressive effect was confirmed, but TG and free fatty acid levels in the blood tended to be suppressed. In the digestive resistance test, the lipase inhibition activity of protamine was maintained after the reaction in the stomach. Therefore, we propose that protamine is an anti-obesity material.

Journal

Citations (1)*help

See more

References(22)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top