Drink Containing Adzuki Polyphenol Inhibits Weight Gain in Female Mice on High-Fat Diets
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- Kojima Michiyuki
- Department of Food Production Science, Obihiro University
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- Nishi Shigenori
- Department of Food Production Science, Obihiro University
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- Saito Yusuke
- Department of Food Production Science, Obihiro University
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- Hironaka Kazunori
- Department of Food Production Science, Obihiro University
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- Koaze Hiroshi
- Department of Food Production Science, Obihiro University
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- Maeda Ryuichiro
- Department of Basic Veterinary Science, Obihiro University
Bibliographic Information
- Other Title
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- 小豆ポリフェノール飲料による高脂肪食投与雌マウスの体重増加抑制
- アズキ ポリフェノール インリョウ ニ ヨル コウシボウショク トウヨ メス マウス ノ タイジュウ ゾウカ ヨクセイ
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Abstract
Hepatic disorders were absent in female mice given both a high-fat diet and a drink containing adzuki polyphenol (APP) for seven weeks, with no significant difference observed in the amount of feces between the experimental and control (high-fat diet only) mice. However, the average weight of mice given the APP drink was significantly lower than that of control mice, and the difference in the weight of ovary circumference fat was particularly marked. Additionally, the fat content of the feces of the mice given the APP drink was significantly higher than that of control mice, indicating greater fat elimination via the feces. An in vivo experiment found an inhibitory effect on pancreatic-lipase-activity dependent on an APP concentration with an IC50 of 38.0ppm. Based on these results, it was suggested that in female mice given both a high-fat diet and the APP drink for a long period of time, APP inhibits pancreatic lipase activity, thus blocking the digestion and absorption of dietary fat and promoting fat elimination in the feces, thereby controlling weight gain.
Journal
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- Nippon Shokuhin Kagaku Kogaku Kaishi
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Nippon Shokuhin Kagaku Kogaku Kaishi 54 (5), 229-232, 2007
Japanese Society for Food Science and Technology
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Details 詳細情報について
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- CRID
- 1390282681384758656
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- NII Article ID
- 130000051581
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- NII Book ID
- AN10467499
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- COI
- 1:CAS:528:DC%2BD2sXmtlWlsb0%3D
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- ISSN
- 18816681
- 1341027X
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- NDL BIB ID
- 8801442
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed