Dietary Trypsin Inhibitors Lower Serum Triacylglycerol Level in Rats

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  • Tashiro Misao
    Department of Food and Nutrition, School of Human Environmental Sciences, Mukogawa Women's University
  • Sawada Sayuri
    Department of Food and Nutrition, School of Human Environmental Sciences, Mukogawa Women's University
  • Takeda Saki
    Department of Food and Nutrition, School of Human Environmental Sciences, Mukogawa Women's University

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  • 食餌性トリプシンインヒビターはラットの血清中性脂肪を低下させる
  • ショクジセイ トリプシン インヒビター ワ ラット ノ ケッセイ チュウセイ シボウ オ テイカサセル

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As dietary trypsin inhibitors are thought to cause alteration in exocrine pancreatic function that results in increased energy expenditure, we investigated whether these inhibitors affect lipid metabolism in humans or experimental animals. Five-week-old male Wistar rats were fed experimental diets of a 20% casein control diet or trypsin inhibitor (TI) diets containing 0.2% Japanese quail ovomucoid or rice bran trypsin inhibitor for 3 weeks. Liver and serum lipids were measured and pancreata were collected for trypsin, chymotrypsin, and amylase assays. No significant differences were observed in feed intake and body weight gain between the control and TI groups. The TI groups had significantly lower serum triacylglycerol levels, yet no change in liver and serum cholesterol levels. Dietary TIs led to increased pancreatic weights and elevated trypsin, chymotrypsin, and amylase levels in the pancreata. These findings support our hypothesis that dietary TIs affect lipid metabolism. Moreover, we found that dietary TIs have a serum triacylglycerol-lowering function related to the increased pancreatic function.

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