Inhibitory Effect of Crude-Drug Extracts on the Degranulation of Mast Cells (RBL-2H3)

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  • Asano Mariko
    School of Human Environmental Sciences, Mukogawa Women's University
  • Dohi Megumi
    School of Human Environmental Sciences, Mukogawa Women's University
  • Yazawa Kazunaga
    The Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology
  • Kometani Takashi
    Ezaki Glico Co., LTD.
  • Takahashi Kyoko
    School of Human Environmental Sciences, Mukogawa Women's University

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  • ラット好塩基球白血病細胞における生薬抽出液の脱顆粒抑制作用
  • ラット コウエンキキュウ ハッケツビョウ サイボウ ニ オケル ショウヤク チュウシュツエキ ノ ダツカリュウ ヨクセイ サヨウ

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Abstract

The prevalence of type I allergies, including food allergies and atopic dermatitis is increasing worldwide. Chinese medicines and crude drugs have been used for treatment of these allergies ; however, the mechanisms of the treatment effects remain unclear. In the present study, we investigated the inhibitory effects of crude drugs on the degranulation of mast cells using the crude hot-water extracts of 83 types of crude drugs. Among the crude drugs, extracts from Ni-kei, fun-bo-i, ku-se-ki and on-ji most significantly inhibited the release of β-hexosaminidase in RBL-2H3 cells, with IC50 values of 215.7, 79.1, 187.6 and 288.1μg/ml, respectively.

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