Hyaluronidase-inhibitory Activity of Rhamnan Sulfate Obtained from Cultivated <i>Monostroma nitidum </i>(Hitoegusa)

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  • 養殖ヒトエグサ由来ラムナン硫酸のヒアルロニダーゼ阻害活性
  • ヨウショク ヒトエグサ ユライ ラムナン リュウサン ノ ヒアルロニダーゼ ソガイ カッセイ
  • Hyaluronidase-inhibitory activity of rhamnan sulfate obtained from cultivated Monostroma nitidum (Hitoegusa)

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<p>The hyaluronidase-inhibitory activity of rhamnan sulfate, a sulfated polysaccharide obtained from cultivated Monostroma nitidum, was investigated in a hyaluronidase inhibition study using different concentrations (0.1 to 0.2mg/mL) of rhamnan sulfate. Consequently, rhamnan sulfate showed a concentration-dependent enhancement of the inhibition rate. In another hyaluronidase inhibition study, sulfated polysaccharides (fucoidan, porphyran, κ-carrageenan, λ-carrageenan, and rhamnan sulfate) were used to examine the relationship between the inhibition rate and the sulfate group content. Results showed that the activity tended to intensify with increases in the sulfate group content of sulfated polysaccharides, suggesting a strong association between the activity and the sulfate group.</p>

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