PCBの長期間投与によるコイ薬物代謝酵素活性の誘導とその持続性

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タイトル別名
  • Studies on the induction of drug-metabolizing enzymes in fish and shellfish. I Induction of drug-metabolizing enzymes by long-term administration of PCB and duration of their induced activities in carp.
  • PCBの長期間投与によるコイ薬物代謝酵素活性の誘導とその持続性〔英文〕
  • PCB ノ チョウキカン トウヨ ニ ヨル コイ ヤクブツ タイシャ コウソ

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A study was made of the induction of drug-metabolizing enzymes by a long-term administra-tion of PCB-diet and also the duration of their induced activities in the hepatopancreas of carp Cyprinus carpio.<br> In a preliminary experiment comparing the inductivity of hepatic drug-oxidase, PCB among the tested environmental contaminants was most effective as the inducer of cytochrome P-450. Therefore, a subsequent experiment was performed to elucidate the effect of long-term administra-tion of PCB (0.05mg/100g-body weight/day) for 16 weeks on drug-metabolizing enzymes in the hepatopancreas of carp. The dietary administration of PCB induced not only the cyt. P-450 content and the activities of aryl hydrocarbon hydroxylase and O-dealkylase, but also the glutathione content and the activities of glutathione- and UDPglucuronosyl-transferase. However, the in-crease of these contents and activities during PCB administration occurred mostly within 2- or 4- week period, resulting in almost no further increase in spite of the continuous PCB administration for 16 weeks. The induced contents and activities were kept for a fairly long time even after dis-continuance of PCB administration.

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  • 日本水産学会誌

    日本水産学会誌 53 (3), 487-491, 1987

    公益社団法人 日本水産学会

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