Chemotherapeutic study of josamycin against streptococcal infection in cultured yellowtail. I. Efficacy of josamycin against experimental streptococcal infection in cultured yellowtail.

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  • Kusuda Riichi
    Fish Disease Laboratory, Faculty of Agriculture, Koch University
  • Takemaru Iwao
    Fish Disease Laboratory, Faculty of Agriculture, Koch University

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Other Title
  • 養殖ブリ連鎖球菌症に対するジョサマイシンの化学療法学的研究　Ｉ　　実験的ブリ連鎖球菌症に対するジョサマイシンの有効性
  • 実験的ブリ連鎖球菌症に対するジョサマイシンの有効性
  • ジッケンテキ ブリ レンサ キュウキンショウ ニ タイスル ジョサマイシン ノ

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Abstract

Efficacy of josamycin (JM) against experimental streptococcal infection in cultured yellowtail was evaluated. Two procedures were used in this experiment. One was bioautographic technique to confirm efficacy of JM in vivo and the other was a practical study to establish the effective dose against experimentally infected yellowtail. JM medicated feed was orally adiministered in each study. Experimental infection was performed by intramuscular injection in the bioautographic study and intraperitoneal injection in the clinical study. In the bioautographic study, JM dis-played in vivo antimicrobial activity. Fishes administered with 25mg/kg of JM excluded pathogen in the muscle after 6 hours. In the practical study, doses of 20mg/kg/day for 5 days and 30mg/kg/day for 3 days were effective against yellowtail infected with 5.8×108cfu/fish pathogen, which is the infeetive dose to kill 90% of the infected yellowtail in 7 days. However, in the experimental injection, the bacterial concentration influenced the JM therapeutic ability. Effective dose depended on the disease condition of yellowtail. The results suggest possibility to be able to control the streptococcicosis of naturally infected yellowtail.

Journal

  • NIPPON SUISAN GAKKAISHI

    NIPPON SUISAN GAKKAISHI 53 (9), 1519-1523, 1987

    The Japanese Society of Fisheries Science

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