Rhodococcus (Corynebacterium) equi肺内感染マウスにおける肺の食細胞応答について

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  • Bronchoalveolar phagocytic cell response to pulmonary infection of mice with Rhodococcus (Corynebacterium) equi.
  • Rhodococcus(Corynebacterium)equi肺内感染マウスにおける肺の食細胞応答について〔英文〕
  • Rhodococcus Corynebacterium equi ハイ ウチ

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The bronchoalveolar cell response was studied by pulmonary lavage after intratracheal inoculation of Rhodococcus (Corynebacterium) equi in mice. The phagocytic cell response in the lungs depended on the size of the inoculum. A few cells were recruited to the lungs following deposition of small inocula (103 and 105 CFU). However, a large number of neutrophils were recruited to the lungs following deposition of a large inoculum (107 CFU). The effect of nitrogen mustard on early pulmonary clearance was investigated with this infection model in mice. Nitrogen mustard induced leukopenia, resulting in a slight influx of neutrophils into the lungs and permitted the multiplication of the bacteria in the lungs. After accumulation and dispersion of neutrophils, which caused rapid reduction of the number of inoculated bacteria, a number of macrophage infiltrated into the lungs. The effect of carrageenan on pulmonary clearance of R. equi became more prominent after 3 days post infection. These results indicated that resident alveolar macrophages were adequate to clear small numbers of R. equi, but neutrophils were required to clear larger numbers of R. equi in the antibacterial pulmonary defense of mice.

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