ネコ汎白血球減少症ウイルス接種SPFネコにおける臨床・血液・病理学的所見

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  • Clinical, hematological, and pathological findings in specific pathogen-free cats experimentally infected with feline panleukopenia virus.
  • ネコ汎白血球減少症ウイルス接種SPFネコにおける臨床・血液・病理学的所見〔英文〕
  • ネコ ハン ハッケッキュウ ゲンショウショウ ウイルス セッシュ SPF ネコ

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Clinical, hematological, and pathological studies of experimental feline panleukopenia (FPL) were carried out on 10 specific pathogen-free cats. The main clinical signs of the cats infected with FPL virus were mild diarrhea, mild transient pyrexia, depression, and anorexia. None of the cats died. In many cases, leukopenia involving neutropenia and lymphopenia were observed, though the lowest leukocyte count was approximately 6, 000/μl. Hypoplastic changes of myeloid and erythroid cells in the aspirated bone marrow, paticularly decrease of immature cells, were most common. However, recovery of the cells was very rapid. The main histopathological changes of the experimental cats were observed in lymphatic tissues. Depletion of lymphocytes and activation of the RES in the spleen and mesenteric lymph nodes, atrophy of lobules, and depletion of lymphocytes in the thymus were predominant. In addition, intranuclear inclusion bodies were found in the reticular cells of lymphatic tissue and crypt epithelial cells of the small intestine. These results indicate that the clinical, hematological, and pathological changes of experimental FPL in SPF cats are mild and that recovery from the disease is very rapid.

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