Development and Clinical Application of PRF Membranes to Enhance Periodontal Regenerative Therapy

Kawase Tomoyuki

doi:10.5360/membrane.40.118

Platelet–rich fibrin (PRF) was developed as an advanced form of platelet–rich plasma (PRP) and it is widely used as a source of growth factors for tissue regeneration. From this bio material, our laboratory made two important modifications. One was a thin PRF membrane prepared by the use of a novel PRF compression device. This method was capable of minimizing the loss of platelets and bio active growth factors and thereby enabled the PRF membrane to more effectively stimulate cell proliferation and neovascularization. To further clinically enhance the modified PRF membrane, it was exposed to mild heat compression technique. The heat compressed membrane was found to exhibit a longer period, three to four weeks, of chemical/physical stability. However, non–treated PRF membrane was resorbed within two weeks or less at implantation sites and therefore could barely maintain sufficient stability over an adequate amount of time for periodontal regeneration (bone and connective tissue). Compared with the control non–heat exposed gauze–compressed PRF, the resulting heat modified PRF membrane exhibited greater plasmin-resistant and remained stable for a significantly longer time period both in vitro and in vivo. Although additional modification may be required to further improve its clinical applicability, we suggest that this new modified membrane would be a promising bio material for guided tissue regeneration (GTR) treatment with the added advantage over currently available GTR membranes of contributing growth factors to improve regeneration potential.

Development and Clinical Application of PRF Membranes to Enhance Periodontal Regenerative Therapy

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