マイクロ流路を用いたシート状・管状生体組織材料の作製

  • 山田 真澄
    千葉大学大学院工学研究科 共生応用化学専攻
  • 関 実
    千葉大学大学院工学研究科 共生応用化学専攻

書誌事項

タイトル別名
  • Development of Sheet–shaped/Tubular Biological Materials Using Microfluidics
  • マイクロ リュウロ オ モチイタ シートジョウ ・ カンジョウ セイタイ ソシキ ザイリョウ ノ サクセイ

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説明

Microfluidic technologies are capable of producing small materials such as particles, fibers, and sheets with sizes of several hundred micrometers. In this paper, we briefly introduce our recent progresses on the fabrication of hydrogel materials for tissue engineering using microfluidic devices. The first topic is the production of thin, stripepatterned sheets made of alginate hydrogel, having soft and solid regions. These functional hydrogel sheets were used to generate heterotypic cellular constructs composed of hepatocytes and non-parenchymal cells, for the purpose of upregulating hepatic functions. The second topic is the formation of vascular–tissue like tubular structures composed of alginate hydrogel and two types of cells, within hydrogel microchannels made of agarose hydrogel. These studies are good examples of the application of microfluidic devices to the production of thin hydrogel materials that are potentially useful for various biological research and tissue engineering.

収録刊行物

  • 膜 40 (3), 137-142, 2015

    日本膜学会

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