書誌事項
- タイトル別名
-
- Effects of Proton Pump Inhibitors SCH 28080, SPI-447 and Rebeprazole on the Gastric Phospholipid Flippase Activity.
- イ リン シシツ フリッパーゼ カッセイ ニ オヨボス プロトン ポンプ ソガイザイ SCH28080 SPI 447 Rabeprazole ノ エイキョウ
この論文をさがす
抄録
The gastric phospholipid flippase has been found in isolated gastric vesicles. Fluorescence analogues of phospholipid and endogenous phospholipids were translocated from the outer to inner leaflet of the lipid bilayer membrane of hog gastric vesicles in an ATP-dependent manner. Previously we found that the flippase activity in gastric vesicles was inhibited by a K+-competitive specific inhibitor of the gastric H+, K+-ATPase, 2-methyl-8- (phenylmethoxy) imidazo [1, 2-a] pyridine-3-acetonitoril (SCH 28080). Here, we studied effects of other gastric proton pump inhibitors on the flippase activity. We found that another K+-competitive specific inhibitor of the gastric H+, K+-ATPase, 3-amino-5-methyl-2- (2-methyl-3-thionyl) imidazo [1, 2-a] thieno [3, 2-c] pyridine (SPI-447) also inhibited the flippase activity. A substituted benzimidazole-related gastric H+, K+-ATPase inhibitor, 2- {[4- (3-methoxypropoxy) -3-methylpyridin-2-ly] methylsulfinyl}-1H-benzimidazole (rabeprazole) decreased the phospholipid flippase activity to 80.6 ± 14.8% (n = 3) of the control level whereas it decreased the proton pump K+-ATPase activity to 5.6 ± 3.4% (n = 3) of the control level. These results indicated a possibility that the phospholipid flippase activity of hog gastric vesicles is part of the H+, K+-ATPase reaction, although further studies are required to confirm this possibility.
収録刊行物
-
- 膜
-
膜 25 (6), 324-331, 2000
日本膜学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282681398353792
-
- NII論文ID
- 10007828194
-
- NII書誌ID
- AN0023215X
-
- ISSN
- 18846440
- 03851036
-
- NDL書誌ID
- 5579208
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可