Superficial eosinophilic gastritis in laboratory beagle dogs attributable probably to diet.

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  • 実験用ビーグル犬における飼料性と思われる好酸球性表層性胃炎の頻発
  • 実験用ビーグル犬における飼料性と思われる好酸球性表層性胃炎の頻発〔英文〕
  • ジッケンヨウ ビーグルケン ニ オケル シリョウセイ ト オモワレル コウサン

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Abstract

Stomach tissues from 222 beagle dogs, which were used for toxicological studies, were examined histopathologically. Out of 190 dogs fed the same diet, 185 had gastric lesions, whereas all of 32 dogs fed another diet were free from them. The gastric lesions were noted as an accumulation of eosinophils, infiltration of inflammatory cells including lymphocytes, plasma cells and histiocytes in the gastric lamina propria, formation of foregin body type multinucleated giant cells, focal desquamation and papillary proliferation of mucosal epithelium. The lesions were confined to the superficial layer of the antral and pyloric mucosa, and neither desmoplasia nor clinical signs were seen. Multinucleated giant cells often contained amphophilic foreign bodies of varying appearance with inconsistent reaction for periodic acid-Schiff (PAS), but no definite causal agents were detected.

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