正常犬における食餌後の血清胆汁酸濃度および高速液体クロマトグラフィーによる胆汁酸の分画

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  • Postprandial changes in serum bile acids concentration and fractionation of individual bile acid by high performance liquid chromatography in normal dogs.
  • 正常犬における食餌後の血清胆汁酸濃度および高速液体クロマトグラフィーによる胆汁酸の分画〔英文〕
  • セイジョウ イヌ ニ オケル ショクジゴ ノ ケッセイ タンジュウサン ノウド

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Serial determination of serum bile acids (SBA) concentration and its fractionation after feeding were performed in 8 healthy dogs. The mean preprandial SBA was 1.07±0.91μM/l. The mean SBA reached a maximum value of 10.35±7.32μM/l at 6 hour with very rapid risd at 1 hour after feeding. There were no significant differences in any of the mean SBA values during the 1 to 8 hour postprandial period. The mean preprandial triglycerides (TG) concentration was 37.07±13.51mg/dl. The mean TG increased rapidly after feeding and reached a maximum value of 73.53±12.01mg/dl at 2 hour. It would appear that postprandial sample for SBA can be taken at 1 hour after feeding. Unfortunately, none of the peaks was identified in the fractionation study. An unidentified peak with a retention time near 6.4min. increased significantly in the 2 hour sample. A new unidentified peak with a retention time near 9.0min. appeared in the 2 hour sample.

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